Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.
In an attempt to define clinically relevant models of akinesia and dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, we have examined the effects of drugs with high (L-DOPA) vs. low (bromocriptine) dyskinesiogenic potential in Parkinson's disease on three types of motor performance, namely: (i) abnormal involuntary movements (AIMs) (ii) rotational behaviour, and (iii) spontaneous forelimb...
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In transplantation research on Parkinson's disease, behavioral evidence of graft-specific improved function is as necessary as anatomical or chemical data in evaluating the success of the procedure. The circling model of Ungerstedt has been widely adopted to provide such evidence, in part because it is so convenient and (relative to primate models) inexpensive. In this model 6-hydroxydopamine (...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2016
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2016.05.004